A condition characterized by the body's inability to respond to and use insulin that it produces, meaning that insulin cannot function properly and higher levels of insulin are needed to achieve the same effects. This can result in high blood glucose levels and high levels of insulin in the blood. If allowed to worsen, pre-diabetes and type 2 diabetes can develop. Insulin resistance develops in people who have a family history of it, in people who are overweight, and in people who live a sedentary lifestyle. It is also one of the conditions included in the metabolic syndrome.