Diabetes Forecast

Insulin Plus Type 2 Drugs Fight Weight Gain and Improve Control


Researchers are exploring the use of certain type 2 diabetes medications along with insulin in people with type 1 diabetes. The idea? They may reduce weight and further lower blood glucose levels without an increase in low blood glucose (hypoglycemia). In two studies, together involving over 1,600 adults with type 1 diabetes, the addition of two different oral type 2 medications from the SGLT-2 inhibitor class lowered A1C without causing hypoglycemia. In a third study, researchers added injections of a type 2 drug from the GLP-1 receptor agonist class to insulin in 46 people with type 1 diabetes. After a year, their A1C levels had dropped without an increase in lows. The studies’ participants lost some weight with both types of drugs. Researchers are optimistic about the use of both drugs, although they do caution that SGLT-2s have a black box warning from the Food and Drug Administration (FDA) because they can lead to diabetic ketoacidosis (DKA, a metabolic imbalance associated with high blood glucose that can be dangerous if not caught early), sometimes even when blood glucose levels are within the normal range. They’re not indicated for the treatment of type 1.
The American Diabetes Association 78th annual Scientific Sessions.



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