Metformin for Type 1?
Metformin is an inexpensive drug used to treat type 2 diabetes, but a study suggests it might be a useful addition to insulin treatment to improve health for some kids with type 1 diabetes. In a study of 90 kids ages 8 to 18 whose body mass indexes (BMI, a ratio of weight to height used to estimate how close a person is to a healthy weight) were in the top half for their age group, half took daily metformin while the others took a placebo pill. After a year, insulin doses dropped in the metformin group, and their overall glucose control improved. What’s more, blood vessel function—important for preventing heart disease, a dangerous complication of diabetes—had improved in the kids taking metformin but not in those on the placebo medication. The downside: 49 percent of those who took metformin experienced stomach discomfort, compared with only 31 percent who took the placebo.
Source: The Journal of Clinical Endocrinology & Metabolism, published online Oct. 9, 2017