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Gastric Bypass Boosts Insulin Secretion

In most people who have gastric bypass surgery, type 2 diabetes goes into remission. The question is why. In a small study, researchers found that the path food takes through the gastrointestinal tract affects how much insulin the body produces and may be the key to diabetes remission. Gastric bypass surgery involves restructuring the stomach and intestines, routing food around a wide swath of its normal digestive path. Researchers compared insulin levels in bypass surgery patients who had eaten a meal by mouth and after later receiving the same meal through a tube inserted into the bypassed region of the gut. They found that a meal by mouth that skipped over part of the digestive route increased insulin levels 4.6 times more than the direct-to-gut meal. Gastric bypass seems to restore effective insulin secretion by changing the route food takes in the gut.
Source: The Journal of Clinical Endocrinology & Metabolism, May 2013



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