Diabetes Forecast

A New Molecule May Help Lower Blood Glucose


Researchers discovered a new molecule, called KL001, which may someday help lower blood glucose in people with diabetes by suppressing glucose production in liver cells. KL001 works by blocking the breakdown of cryptochrome, a protein that sets the body's biological clock. Cryptochrome boosts metabolism because it lengthens the body's "day," when the body works to absorb and burn incoming calories. When cryptochrome becomes scarce, the body switches into "night" mode, when the liver produces extra glucose to keep energy levels up during sleep. KL001 prevents liver cells from producing excess glucose by keeping cryptochrome levels high. These results are preliminary and need to be confirmed in animal and human trials.
Source: Science, July 12, 2012



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