Promising Type 2 Drug
A novel drug successfully lowered blood glucose levels in people with type 2 diabetes, researchers reported, without increasing the risk for low blood glucose (hypoglycemia). People taking the experimental drug TAK-875 once daily for three months lowered their A1Cs (average blood glucose over the previous two to three months) an average of 1.1 percentage points. TAK-875 activates a protein called the free fatty acid receptor that is found in the pancreas. When it interacts with fats in the body, the protein can trigger the release of insulin, but only if glucose levels are rising. This glucose dependence helps TAK-875 control blood glucose without causing hypoglycemia, the researchers say. Longer and larger studies are needed to determine whether the drug is safe and effective.
Source: The Lancet, published online Feb. 27, 2012